Insanium Essence is an additional tier above Supremium that can be used to craft higher end items such as Nether Star seeds.
Paxels are a 3-in-1 tool made from a Pickaxe, Axe and Shovel.
Pickaxe, Axe, and Shovel augments can be applied to Paxels.
Mystical Agradditions adds support to Tinkers' Construct for Mystical Agriculture materials. Melt down Supremium Ingots in a Smeltery and pour out your new Pickaxe head.